Pendrill Jones was a son of Dr. Charles Morgan Jones, of Troedyrhiw, Glamorgan. As a son of Dr Jones, who was a general practitioner in a mining district, and of Margaret Jenkins whose family were in big business in the coal industry, he seems to have inherited characteristics exactly suited to that rare combination of an interest in medicine and a flair for dealing with unusual industrial problems, and so to his life’s work in the foundation and development of Papworth Village Settlement. He was educated at Epsom College. Wycliffe College, and Stonehouse before proceeding to St. John’s College. Cambridge, where he graduated in 1905 with first-class in the Natural Science Tripos.

For a time, he was house physician at St. Bartholomew’s Hospital, London. where he was Wix Prizeman, and later undertook research work at Cambridge University Medical Schools. He received his knighthood in 1931 and became a Fellow of the Royal College of Physicians (London) in 1934.
He told a “Western Mail” representative, how the village settlement was run. He said it was to provide a suitable environment for the consumptive in which the disease could be definitely checked, and in which the patients can earn a livelihood.”

One of the war's much publicised corollaries is the increased incidence of tuberculosis. This is an opportune, time, therefore, for the publication in book form of the late, Sir Pendrill Varrier-Jones' letters and papers on the principles and practice of the “Papworth Village Settlement,” with which his name will be associated honourably for many a long day.